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It is thought that hormonal changes such as this hypocortisolism may result in symptoms of fatigue experienced by patients (255, 428, 429)

Concurrently, vitamin B12 deficiency was identified as a significant public health concern, particularly among vulnerable populations such as the elderly and developing embryos, where insufficient B12 levels have been associated with an increased risk of neural tube defects

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It is newly reported that iron is correlated with parkinsonism symptoms in a PD mouse model with mutation in Pla2g6 gene (phospholipase A2 group VI), and that iron-catalyzed lipid oxidation modification reduces glutathione peroxidase 4 activity and content 8 , which is related closely to PD